10549-91-4

Basic information

• Product Name: 9,11beta-dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate)
• Synonyms: 9,11beta-dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate);Meclorisone;9,11β-Dichloro-16α-methyl-17,21-bis(1-oxobutoxy)pregna-1,4-diene-3,20-dione;Sch-11572
• CAS NO: 10549-91-4
• Molecular Formula: C30H41Cl2O8
• Molecular Weight: 600.54774
• EINECS: 234-132-7
• Mol File: 10549-91-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 641.5°Cat760mmHg
• Flash Point: 183.5°C
• Appearance: /
• Density: 1.24g/cm³
• CAS DataBase Reference: 9,11beta-dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate)(CAS DataBase Reference)
• NIST Chemistry Reference: 9,11beta-dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate)(10549-91-4)
• EPA Substance Registry System: 9,11beta-dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate)(10549-91-4)

Safety Data

• Hazardous Substances Data: 10549-91-4(Hazardous Substances Data)

Usage

Description

9,11beta-dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate), also known as Meclorisone Dibutyrate, is a synthetic corticosteroid derived from the pregnane class of steroid hormones. It is characterized by the presence of chlorine atoms at the 9 and 11 beta positions, and hydroxyl groups at the 17 and 21 positions. The molecule also features a 16alpha-methyl group and a 1,4-diene structure, with a 3,20-dione functional group. The butyrate esters at the 17 and 21 positions contribute to its lipophilic nature, enhancing its penetration through biological membranes.

Uses

Used in Pharmaceutical Industry:
9,11beta-dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate) is used as an anti-inflammatory agent for the treatment of various skin conditions, such as eczema, dermatitis, and psoriasis. Its potent anti-inflammatory and immunosuppressive properties make it an effective treatment for reducing inflammation, itching, and redness associated with these conditions.
Used in Topical Steroid Optimization:
In the pharmaceutical industry, Meclorisone Dibutyrate is used to optimize the bioavailability of topical steroids in humans. The thermodynamic control of its formulation enhances the drug's penetration through the skin, leading to improved efficacy and reduced systemic side effects.
Used in Anti-inflammatory Applications (Topical):
9,11beta-dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate) is used as a topical anti-inflammatory agent for the relief of inflammation and associated symptoms in various skin conditions. Its lipophilic nature allows for better penetration and absorption through the skin, providing targeted relief and minimizing the risk of systemic side effects.