105492-12-4

Basic information

• Product Name: 3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE
• Synonyms: 3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE
• CAS NO: 105492-12-4
• Molecular Formula: C₁₅H₁₃N₃O
• Molecular Weight: 251.28
• Mol File: 105492-12-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 238-240°C
• Appearance: /
• Density: 1.29 g/cm³
• Refractive Index: 1.704
• PKA: 13.10±0.30(Predicted)
• CAS DataBase Reference: 3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE(105492-12-4)
• EPA Substance Registry System: 3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE(105492-12-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 105492-12-4(Hazardous Substances Data)

Usage

General Description

3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE, also known as phenylindole carbohydrazide, is a chemical compound with the molecular formula C15H14N4O. It is a white to off-white solid that is insoluble in water but soluble in organic solvents such as dimethyl sulfoxide and ethanol. 3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE is commonly used in organic synthesis and pharmaceutical research as a building block for various heterocyclic compounds and potential drug candidates. It has also shown potential antitumor and antimicrobial activity in preliminary studies, making it a promising candidate for further research and development.

InChI:InChI=1/C15H13N3O/c16-18-15(19)14-13(10-6-2-1-3-7-10)11-8-4-5-9-12(11)17-14/h1-9,17H,16H2,(H,18,19)

Upstream product

• 52839-31-3 3-phenyl-indole-2-carbonyl chloride 
• 37129-23-0 ethyl 3-phenyl-1H-indole-2-carboxylate 
• 6915-67-9 3-phenyl-1H-indole-2-carboxylic acid 

Downstream Products

• 121649-71-6 3-phenyl-indole-2-carboxylic acid benzylidenehydrazide 
• 105492-16-8 3-Phenylindole-2-carboxazide 
• 211749-49-4 3-Phenyl-1H-indole-2-carboxylic acid N'-(2-hydroxy-benzyl)-hydrazide 
• 211749-55-2 3-Phenyl-1H-indole-2-carboxylic acid N'-(2-hydroxy-5-methyl-benzyl)-hydrazide 
• 105492-24-8 3-Phenylindole-2-semicarbazide 
• 105492-20-4 Ethyl 3-phenylindole-2-carbamate 
• 121650-01-9 3-(3'-phenyl-indole-2'-carboxamido)-2-phenylimino-4-thiazolidinone 
• 121649-95-4 3-Phenyl-1H-indole-2-carboxylic acid (4,6-dioxo-3-phenyl-2-thioxo-tetrahydro-pyrimidin-1-yl)-amide 
• 126016-47-5 3-phenyl-2-(5'-mercapto-4'-phenyl-1',2',4'-triazol-3'-yl)indole 
• 126016-19-1 3-phenyl-2-(5'-phenylamino-1',3',4'-oxadiazol-2'-yl)indole 
• 126016-33-9 3-phenyl-2-(5'-phenylamino-1',3',4'-thiadiazol-2'-yl)indole 
• 375822-27-8 N'((4-bromophenyl)methylidene)-3-phenyl-1H-indole-2-carbohydrazide 

Relevant articles and documents

3-substituted indole antiproliferative angiogenesis inhibitors

3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.

Synthesis of Substituted 1,2,3,8-Tetrahydroindolobenzodiazepin-2-ones and 5,6,7,8-Tetrahydroindolobenzodiazepin-6-ones

Nitrosation (NaNO2/AcOH) of 2-phenylindoles (1a-d) and subsequent reduction of the resultant 3-nitroso-2-phenylindoles (2a-d) with sodium dithionite in alkali furnish the corresponding 3-aminoindoles (3a-d), which on condensation with ethyl chloroformate