105526-91-8

Basic information

• Product Name: (S)-1-((R)-3-Methyl-pentanoyl)-5-trityloxymethyl-pyrrolidin-2-one
• Synonyms: (S)-1-((R)-3-Methyl-pentanoyl)-5-trityloxymethyl-pyrrolidin-2-one
• CAS NO: 105526-91-8
• Molecular Weight: 455.597
• Mol File: 105526-91-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-((R)-3-Methyl-pentanoyl)-5-trityloxymethyl-pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-((R)-3-Methyl-pentanoyl)-5-trityloxymethyl-pyrrolidin-2-one(105526-91-8)
• EPA Substance Registry System: (S)-1-((R)-3-Methyl-pentanoyl)-5-trityloxymethyl-pyrrolidin-2-one(105526-91-8)

Safety Data

• Hazardous Substances Data: 105526-91-8(Hazardous Substances Data)

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 
• 105526-85-0 (S)-5-(trityloxymethyl)pyrrolidin-2-one 
• 56-86-0 L-glutamic acid 
• 105526-86-1 (5S)-N-[(2E)-but-2-enoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone 
• 2386-64-3 ethylmagnesium chloride 

Downstream Products

• 16958-25-1 (R)-3-methylpentanoic acid 
• 1730-92-3 (3S)-methylvaleric acid 

Relevant articles and documents

ASYMMETRIC CONJUGATE ADDITION REACTION BY THE USE OF (S)-γ-TRITYLOXYMETHYL-γ-BUTYROLACTAM AS A CHIRAL AUXILIARY

(S)-γ-Trityloxymethyl-γ-butyrolactam (2) serves as a chiral auxiliary in the conjugate addition reaction of the corresponding imide (3) of α,β-unsaturated carboxylic acids with Grignard reagents in the presence of CuBr-SMe2 in THF to give, after hydrolysis, the β,β-disubstituted carboxylic acids (5) with predictable absolute configuration and high enantiomeric excess.