105532-86-3

Basic information

• Product Name: N-METHOXY-N,O-BIS(TRIMETHYLSILYL)CARBAMATE
• Synonyms: N-METHOXY-N,O-BIS(TRIMETHYLSILYL)CARBAMATE;N,O-BIS(TRIMETHYLSILYL)-N-METHOXYCARBAMATE;N-TRIMETHYLSILYL-N-METHOXYCARBAMIC ACID TRIMETHYLSILYL ESTER;Methoxybistrimethylsilylcarbamate;SimultaneoussilylationandmethoximationreagentforGC;N-Methoxy-N,O-bis(trimethylsilyl)carbamate [Simultaneous silylation and methoximation reagent for GC];GCGXSWVZNAVCBH-UHFFFAOYSA-N
• CAS NO: 105532-86-3
• Molecular Formula: C8H21NO3Si2
• Molecular Weight: 235.43
• Product Categories: Analytical Chemistry;GC Derivatizing Reagents;Hydroxylamines;Hydroxylamines (N-Substituted);Hydroxylamines (O-Substituted);Si (Classes of Silicon Compounds);Silyl Esters;Silylation (GC Derivatizing Reagents);Si-N Compounds;Si-O Compounds;Trimethylsilylation (GC Derivatizing Reagents);Trimethylsilylazide, etc.
• Mol File: 105532-86-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 203.067°C at 760 mmHg
• Flash Point: 76.613°C
• Appearance: /
• Density: 0.945g/cm³
• Vapor Pressure: 0.283mmHg at 25°C
• Refractive Index: 1.426
• CAS DataBase Reference: N-METHOXY-N,O-BIS(TRIMETHYLSILYL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXY-N,O-BIS(TRIMETHYLSILYL)CARBAMATE(105532-86-3)
• EPA Substance Registry System: N-METHOXY-N,O-BIS(TRIMETHYLSILYL)CARBAMATE(105532-86-3)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: 1993
• Hazardous Substances Data: 105532-86-3(Hazardous Substances Data)

Usage

General Description

N-Methoxy-N,O-bis(trimethylsilyl)carbamate is a chemical compound commonly used in organic synthesis as a protecting group for amines. It is a derivative of carbamic acid and its primary function lies in the protection of primary and secondary amines, which are usually reactive in organic reactions. The compound is commonly used in the synthesis of various pharmaceuticals and fine chemicals, as well as in the development of new materials. Its trimethylsilyl group provides steric hindrance and prevents unwanted reactions of the amine group, making it a valuable tool in organic chemistry. Additionally, N-methoxy-N,O-bis(trimethylsilyl)carbamate is relatively stable and easily removable under mild conditions, making it a popular choice for amine protection in organic synthesis.

InChI:InChI=1/C8H21NO3Si2/c1-11-9(13(2,3)4)8(10)12-14(5,6)7/h1-7H3

Relevant articles and documents

Trimethylsilylcarbamates and a process for the preparation thereof

The invention relates to new compounds of the general formulae (I) and/or (II), STR1 wherein R1 is a C1-6 alkyl or an aralkyl group, and R2 is hydrogen or a C1-6 alkyl group. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the general formulae (I) and/or (II) are utilizable for the oxymation and/or trimethylsilylation of any substrate bearing an oxo group and/or a silylable polar hydrogen. The compounds of the general formula (VI): wherein R1 is as defined above Y is oxygen, nitrogen or sulphur atom or a carboxylate anion, and Z is the skeleton of the substrate, said compounds being formed in the oxymation and/or trimethylsilylation reaction, are also within the scope of the invention.