105562-13-8 Usage
Description
11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al is a steroidal compound derived from cortisol, specifically an isomer of (11β,17E)-11,20-dihydroxy-3-oxo-pregna-4,17(20)-dien-21-al (D453910). It is characterized by its unique molecular structure, which includes a 3-oxo group and a 21-aldehyde functional group. 11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al is of interest in the field of biochemistry and pharmacology due to its potential roles in various biological processes.
Uses
Used in Pharmaceutical Research:
11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al is used as a research compound for investigating the metabolic pathways and enzyme activities related to steroid metabolism in the liver of mice. Its unique structure allows scientists to study the differences in metabolic reactions between the cis and trans isomers, which can provide valuable insights into the regulation of steroid hormones and their role in various physiological processes.
Used in Biochemical Analysis:
11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al can also be utilized as a reference material in biochemical analysis to compare and identify similar steroidal compounds. Its distinct chemical properties make it a useful tool for characterizing and differentiating other related molecules in complex biological samples.
Used in Drug Development:
Given its structural similarity to cortisol, 11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al may have potential applications in the development of new drugs targeting the glucocorticoid receptor or other related pathways. Further research into its biological activities and interactions with cellular targets could lead to the discovery of novel therapeutic agents for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 105562-13-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,5,6 and 2 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 105562-13:
(8*1)+(7*0)+(6*5)+(5*5)+(4*6)+(3*2)+(2*1)+(1*3)=98
98 % 10 = 8
So 105562-13-8 is a valid CAS Registry Number.
105562-13-8Relevant articles and documents
Synthetic method for 17Z-(1-hydroxy-2-oxo-1- ethylidene) androstenone derivative
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Paragraph 0015, (2017/05/02)
The invention relates to a synthetic method for a 17Z-(1-hydroxy-2-oxo-1- ethylidene) androstenone derivative. The synthetic method comprises the following steps of mixing a catalyst 2-iodobenzoic acid and an oxidant potassium hydrogen persulfate to produce a mixture glucocorticoid, adding a DMSO solvent, performing a mixing and stirring reaction and a quenching reaction, and conducting extraction, washing and drying to boil off the solvent, then performing column chromatography to obtain the target compound 17Z-(1-hydroxy-2-oxo-1- ethylidene) androstenone derivative. (Please see the formula in the description) The synthetic method for the 17Z-(1-hydroxy-2-oxo-1- ethylidene) androstenone derivative has the advantages of being high in selectivity, capable of preparing a single stereoselective product, high in the target compound yield and capable of meeting the needs in scientific researches and practical application.
Synthesis, Isolation, and Characterization of the Cis and Trans Isomers of Steroidal 20-Hydroxy-17(20)-en-21-aldehydes
Lewbart, Marvin L.,Monder, Carl,Boyko, Walter J.,Singer, Carol J.,Iohan, F.
, p. 1332 - 1338 (2007/10/02)
The cis- and trans-17(20)-ene-20-hydroxy-21-aldehydes (enol aldehydes) along with their acetate derivatives were prepared from the parent ketols, cortisol, cortisone, 11-deoxycortisol, prednisolone, and prednisone by reaction with zinc acetate in glacial acetic acid.Separation and isolation of the pure isomers was accomplished for the first time by reversed-phase high-performance liquid chromatography.Stereochemical assignments were based on unequivocal partial syntheses.Significant differences in the ultraviolet spectra, optical rotatory properties, and nuclearmagnetic spectra of the cis and trans isomers were found.The availability of pure enol aldehydes will make possible studies centering on their possible role as intermediates in the metabolism of the ketol side chain.
