1056025-04-7

Basic information

• Product Name: C₆₆H₁₀₄N₂O₅
• Synonyms: C₆₆H₁₀₄N₂O₅
• CAS NO: 1056025-04-7
• Molecular Weight: 1005.56
• Mol File: 1056025-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₆H₁₀₄N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₆H₁₀₄N₂O₅(1056025-04-7)
• EPA Substance Registry System: C₆₆H₁₀₄N₂O₅(1056025-04-7)

Safety Data

• Hazardous Substances Data: 1056025-04-7(Hazardous Substances Data)

Upstream product

• 136918-14-4 phthalimide 
• 160280-70-6 (2S,3S,4R)-2-hexacosylamino-3,4-di-O-benzyl-1,3,4-octadecanetriol 

Downstream Products

• 1056025-08-1 C₅₈H₁₀₂N₂O₃ 

Relevant articles and documents

Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production

The protein CD1d binds self and foreign glycolipids for presentation to CD1-restricted T cells by means of TCR recognition and activates TH1 and TH2 chemokine release. In this study, a variety of glycolipid ligands were attached to a microarray surface and their binding with dimeric CD1d was investigated. An α-galactosyl ceramide (α-GalCer) bearing a carbamate group at the 6′-OH position was tethered to the surface, and the dissociation constant on surface with CD1d was determined to reflect the multivalent interaction. Competition assays were then used to determine the dissociation constants (Ki) of new and intact glycolipids in solution. The 4-fluorophenyloctanoyl-modified α-GalCer (18) was found to bind most strongly with CD1d (Ki 0.21 μM), 2 orders of magnitude stronger than α-GalCer and more than three times more selective than α-GalCer for IFN-γ release from NKT cells. Various α-GalCer analogues were analyzed, and the results showed that the binding affinity of glycolipids to CD1d correlates well with IFN-γ production but poorly with IL-4 secretion by NKT cells, suggesting that tighter binding ligands could bias cytokine release through the TH1 pathway.