10562-70-6Relevant articles and documents
Direct Exploitation of the Ethynyl Moiety in Calcium Carbide Through Sealed Ball Milling
Hosseini, Abolfazl,Schreiner, Peter R.
, p. 4339 - 4346 (2020/07/04)
Ball milling of calcium carbide (CaC2) enables the reaction of its ethynyl moiety with organic electrophiles. This was realized simply by co-milling CaC2 with organic substrates in a sealed jar without the need for an additive or a catalyst. Various ketones including those bearing α-hydrogens were ethynylated in good yields at short reaction times. Aryl halides are also amenable substrates for this protocol as they furnish aryl ethynes through a benzyne intermediate. This method offers a practical and cheap alternative to the established procedures for introducing ethynyl functionalities.
Pd(II)-catalyzed highly regio-and stereoselective assembly of C-C double bonds: An efficient method for the synthesis of 2,4-dihalo-1,3,5-trienes from alkynols
Jiang, Huanfeng,Gao, Yang,Wu, Wanqing,Huang, Yubing
supporting information, p. 238 - 241 (2013/03/13)
A highly efficient method for the synthesis of 2,4-dihalo-1,3,5-trienes from alkynols was developed. This chemistry allows access to multiple conjugated double bonds in a single step with high stereoselectivity.
