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1056225-13-8

1056225-13-8

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1056225-13-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1056225-13-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,6,2,2 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1056225-13:
(9*1)+(8*0)+(7*5)+(6*6)+(5*2)+(4*2)+(3*5)+(2*1)+(1*3)=118
118 % 10 = 8
So 1056225-13-8 is a valid CAS Registry Number.

1056225-13-8Downstream Products

1056225-13-8Relevant articles and documents

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517

Islam, Imadul,Brown, Greg,Bryant, Judi,Hrvatin, Paul,Kochanny, Monica J.,Phillips, Gary B.,Yuan, Shendong,Adler, Marc,Whitlow, Marc,Lentz, Dao,Polokoff, Mark A.,Wu, James,Shen, Jun,Walters, Janette,Ho, Elena,Subramanyam, Babu,Zhu, Daguang,Feldman, Richard I.,Arnaiz, Damian O.

, p. 3819 - 3825 (2008/02/07)

Based on the lead compound BX-517, a series of C-4′ substituted indolinones have been synthesized and evaluated for PDK1 inhibition. Modification at C-4′ of the pyrrole afforded potent compounds (7b and 7d) with improved solubility and ADME properties. In this letter, we describe the synthesis, selectivity profile, and pharmacokinetic data of selected compounds.

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