1056267-89-0 Usage
Description
6-Bromo-2H-1,4-benzoxazine-3(4H)-thione is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a benzoxazine ring and a thione group, as well as a bromine atom at the 6th position. 6-BroMo-2H-1,4-benzoxazine-3(4H)-thione plays a significant role in the development of potent drugs targeting specific biological pathways.
Uses
Used in Pharmaceutical Industry:
6-Bromo-2H-1,4-benzoxazine-3(4H)-thione is used as an intermediate in the synthesis of NS-2028 (N900200), a potent soluble guanylyl cyclase (sGC) inhibitor. The compound exhibits a high affinity for sGC, with a Ki value of 8 nM, making it a valuable tool in the development of drugs targeting this enzyme.
Used in Neurological Applications:
In the field of neurology, 6-Bromo-2H-1,4-benzoxazine-3(4H)-thione is used as a key component in the development of NS-2028, which has been shown to block sGC activity in murine cerebellum induced by S-nitroso-glutathione and N-methyl-D-aspartate (NMDA). This inhibition of sGC activity can be beneficial in the treatment of various neurological disorders and conditions, such as cerebral ischemia and neurodegenerative diseases.
Used in Drug Development:
6-Bromo-2H-1,4-benzoxazine-3(4H)-thione is also used in the development of new drugs with potential applications in various therapeutic areas. Its unique chemical structure allows for the design and synthesis of novel compounds that can modulate specific biological targets, leading to the development of more effective and targeted treatments for a wide range of diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1056267-89-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,6,2,6 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1056267-89:
(9*1)+(8*0)+(7*5)+(6*6)+(5*2)+(4*6)+(3*7)+(2*8)+(1*9)=160
160 % 10 = 0
So 1056267-89-0 is a valid CAS Registry Number.
1056267-89-0Relevant articles and documents
PD-1 inhibitor as well as preparation method and application thereof
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Paragraph 0256-0258, (2021/03/31)
The present invention relates to a compound represented by a formula I, racemates, stereoisomers, tautomers, isotope markers, nitrogen oxide, solvates, polymorphs, metabolites, esters, prodrugs or pharmaceutically acceptable salts thereof, a pharmaceutical composition containing the compounds, a preparation method and a medical use of the compounds, wherein the structure of the formula I is shownin the specification.
Metalloprotease inhibitors containing a heterocyclic moiety
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Page/Page column 17, (2008/12/08)
The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting compounds with a modified benzoxazine moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13 inhibitors.
