1056465-06-5Relevant articles and documents
N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
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Paragraph 000254; 000320; 000321, (2015/05/19)
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
Imidazo[1,2-a]pyridines: Orally active positive allosteric modulators of the metabotropic glutamate 2 receptor
Trabanco, Andrés A.,Tresadern, Gary,MacDonald, Gregor J.,Vega, Juan Antonio,De Lucas, Ana Isabel,Matesanz, Encarnación,García, Aránzazu,Linares, María Lourdes,Alonso De Diego, Sergio A.,Alonso, José Manuel,Oehlrich, Daniel,Ahnaou, Abdelah,Drinkenburg, Wilhelmus,MacKie, Claire,Andrés, José Ignacio,Lavreysen, Hilde,Cid, José María
experimental part, p. 2688 - 2701 (2012/06/01)
Advanced leads of an imidazopyridine series of positive allosteric modulators of the metabotropic glutamate 2 (mGlu2) receptor are reported. The optimization of in vitro ADMET and in vivo pharmacokinetic properties led to the identification of 27o. With g