1057257-37-0Relevant articles and documents
3-Acrylamide-4-aryloxyindoles: Synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists
Zhou, Nian,Zeller, Wayne,Zhang, Jun,Onua, Emmanuel,Kiselyov, Alex S.,Ramirez, Jose,Palsdottir, Gudrun,Halldorsdottir, Gudrun,Andresson, Thorkell,Gurney, Mark E.,Singh, Jasbir
scheme or table, p. 1528 - 1531 (2009/11/30)
A series of potent and selective EP3 receptor antagonists are described. Utilizing a pharmacophore model developed for the EP3 receptor, a series of 3,4-disubstituted indoles were found to be efficient ligands for this target. These compounds showed high selectivity over IP, FP and other EP receptors. An optimized molecule 7c featured a sound profile and potency in the functional rat and human platelet aggregation assays.