1057649-84-9

Basic information

• Product Name: 5-(3-(hydroxy(diphenyl)methyl)pyrrolidin-1-yl)-1-(4-isobutylphenyl)pentan-1-one
• Synonyms: 5-(3-(hydroxy(diphenyl)methyl)pyrrolidin-1-yl)-1-(4-isobutylphenyl)pentan-1-one
• CAS NO: 1057649-84-9
• Molecular Weight: 469.667
• Mol File: 1057649-84-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3-(hydroxy(diphenyl)methyl)pyrrolidin-1-yl)-1-(4-isobutylphenyl)pentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-(hydroxy(diphenyl)methyl)pyrrolidin-1-yl)-1-(4-isobutylphenyl)pentan-1-one(1057649-84-9)
• EPA Substance Registry System: 5-(3-(hydroxy(diphenyl)methyl)pyrrolidin-1-yl)-1-(4-isobutylphenyl)pentan-1-one(1057649-84-9)

Safety Data

• Hazardous Substances Data: 1057649-84-9(Hazardous Substances Data)

Upstream product

• 5731-19-1 diphenyl(pyrrolidin-3-yl)methanol 
• 1057648-27-7 5-bromo-1-(4-isobutylphenyl)pentan-1-one 

Downstream Products

• 1057649-86-1 5-(3-(hydroxy(diphenyl)methyl)pyrrolidin-1-yl)-1-(4-isobutylphenyl)pentan-1-ol 

Relevant articles and documents

Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: Synthesis and structure optimization

Terfenadine (4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-(4-tert- butylphenyl)-butan-1-ol) was identified in a biological screening to be a moderate inhibitor (27 % inhibition) of the CD81-LEL-HCV-E2 interaction. To increase the observed biological activity, 63 terfenadine derivates were synthesized via microwave assisted nucleophilic substitution. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay using HUH7.5 cells. Distinct structure-activity relationships could be derived. Optimization was successful, leading to 3g, identfied as the most potent compound (69 % inhibition). Experiments with viral particles revealed that there might be additional HCV infection reducing mechanisms.