105799-70-0Relevant articles and documents
4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase
Han, Qiang,Pabba, Praveen K.,Barbosa, Joseph,Mabon, Ross,Healy, Jason P.,Gardyan, Michael W.,Terranova, Kristen M.,Brommage, Robert,Thompson, Andrea Y.,Schmidt, James M.,Wilson, Alan G.E.,Xu, Xiaolian,Tarver, James E.,Carson, Kenneth G.
, p. 1184 - 1187 (2016/02/23)
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified.