105804-69-1Relevant articles and documents
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Stratton,Busch
, p. 1286,1287 (1958)
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Synthesis and Characterization of Pyridine End-Capped Oligoazines
Kesslen, Eric C.,Euler, William B.
, p. 4725 - 4728 (1995)
A new group of controlled chain length oligoazine analogues with pyridine end groups are synthesized and characterized.
Chromophore containing bipyridyl ligands. Part 1: Supramolecular solid-state structure of Ag(I) complexes
Kennedy, Alan R.,Brown, Karen G.,Graham, Duncan,Kirkhouse, Jennifer B.,Kittner, Madeleine,Major, Claire,McHugh, Callum J.,Murdoch, Paul,Smith, W. Ewen
, p. 826 - 832 (2005)
The solid-state structures of a series of azine or azo chromophore containing bipyridyl ligand complexes of Ag(i) salts have been determined by single-crystal X-ray diffraction. The supramolecular structures are dominated by one-dimensional chains formed through pyridyl-Ag-pyridyl bonding, but the packing of these chains through non-covalent intermolecular interactions is unpredictable. Ag...anion interactions are shown to be important, especially for nitrate and perchlorate species, but these may be supported or replaced by Ag...Ag, Ag...solvent, Ag...azine or Ag...π contacts. The molecular structures of the ligands show little alteration on complex formation, except for the AgNO3 complex of N,N′-bis-pyridin-4-ylmethylenehydrazine where the normally planar azine ligand adopts a twisted geometry. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2005.
Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease
Shi, Jian,Zhou, Yi,Wang, Keren,Ma, Qinge,Wei, Rongrui,Li, Qingfeng,Zhao, Yiyang,Qiao, Zhanpin,Liu, Shuang,Leng, Yumin,Liu, Wenmin,Sang, Zhipei
, p. 624 - 634 (2020/11/30)
A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted as a highly selective monoamine oxidase-B inhibitor (IC50 = 8.4 nM), which was explained by the docking study. Compound 3b also was an antioxidant agent (2.3 eq) and could significantly inhibit self-induced Aβ1-42 aggregation (31.8%). Meanwhile, compound 3b was a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation (62.3%). Furthermore, compound 3b presented good neuroprotective effects on H2O2-induced PC12 cell injury. More importantly, compound demonstrated good blood brain barrier permeability and druglike properties. Therefore, compound 3b, a promising multi-targeted active molecule, offers an attractive starting point for further study in the drug-discovery process against AD.[Figure not available: see fulltext.].
Synthesis and evaluation of certain symmetrical schiff bases as inhibitors of MDA-MB-241 human breast cancer cell proliferation
Radi, Smaail,Tighadouini, Said,Feron, Olivier,Riant, Olivier,Mabkhot, Yahia N.
, p. 205 - 209 (2016/03/15)
A series of symmetrical Schiff base derivatives (L1-L7) were designed by a one-pot condensation reaction of various aldehyde/ketone compounds with hydrazine under mild conditions (room temperature, 3 days), using ether as solvent and acetic acid as catalyst. The target products were characterized and analysed by 1H and 13C NMR, FT-IR and liquid chromatography mass spectrometry (LC/MS). Our research focuses on the identification of synthetically chemotherapeutic substances able to inhibit, delay, or reverse the process of carcinogenesis in several stages. The target compounds presenting two regions for SAR evaluation were screened for their activity toward MDA-MB-241 breast cancer cell proliferation for the first time. Compound (1E, 2E)-1,2-bis(1-(3-nitrophenyl)ethylidene) hydrazine (L6) showed significant inhibitory activity (IC50 = 7.08 μg/mL).
