1058165-14-2

Basic information

• Product Name: R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid
• Synonyms: R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid
• CAS NO: 1058165-14-2
• Molecular Weight: 402.878
• Mol File: 1058165-14-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid(1058165-14-2)
• EPA Substance Registry System: R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid(1058165-14-2)

Safety Data

• Hazardous Substances Data: 1058165-14-2(Hazardous Substances Data)

Upstream product

• 163837-57-8 (R)-(4-chlorophenyl)(phenyl)methylamine 
• 4480-83-5 1,4-dioxane-2,6-dione 
• 300543-56-0 (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine 

Downstream Products

• 130018-87-0 levocetirizine dihydrochloride 
• 1201648-47-6 R-methyl 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetate 
• 130018-77-8 levocetirizine 
• 1201648-48-7 propyl R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetate 
• 1201648-49-8 trimethylsilyl R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetate 

Relevant articles and documents

NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF

The present invention describes a novel process for the preparation of levocetirizine and pharmaceutically acceptable acid addition salts thereof via a ketocetirizine ester and new ketocetirizine ester intermediates used in that process. reaction of ketocetirizine of the formula (IIIb) to a ketocetirizine ester of the formula (IV) or a salt thereof.