105826-92-4 Usage
Description
Tropisetron hydrochloride, also known as a selective 5-HT3 serotonin receptor antagonist, is a hydrochloride obtained by combining equimolar amounts of tropisetron and hydrogen chloride. It is a white to off-white crystalline solid that plays a significant role in the pharmaceutical industry due to its specific properties.
Uses
Used in Pharmaceutical Industry:
Tropisetron hydrochloride is used as an antiemetic agent for the treatment of nausea and vomiting. It works by blocking the 5-HT3 receptors in the brain, which are responsible for the sensation of nausea and vomiting. This selective 5-HT3 serotonin receptor antagonist helps in reducing the frequency and severity of these symptoms, particularly in patients undergoing chemotherapy, radiation therapy, or surgery.
Used in Oncology:
In the field of oncology, Tropisetron hydrochloride is used as an antiemetic agent to manage the side effects of cancer treatments such as chemotherapy and radiation therapy. These treatments often cause severe nausea and vomiting, which can be debilitating for patients. By blocking the 5-HT3 receptors, Tropisetron hydrochloride helps alleviate these symptoms, improving the patient's quality of life and allowing them to continue with their treatment regimen.
Used in Anesthesia:
Tropisetron hydrochloride is also used in the field of anesthesia as a premedication to reduce the incidence of postoperative nausea and vomiting. By administering the drug before surgery, it helps in minimizing the risk of these side effects, which can be particularly distressing for patients and may prolong their recovery time.
Used in Gastroenterology:
In gastroenterology, Tropisetron hydrochloride is used as an antiemetic agent to treat gastrointestinal disorders that cause nausea and vomiting, such as gastroparesis, irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD). By blocking the 5-HT3 receptors, it helps in reducing the frequency and severity of these symptoms, improving the patient's overall well-being.
Biological Activity
Potent, orally active 5-HT 3 receptor antagonist. Antiemetic.
Biochem/physiol Actions
Tropisetron a selective serotonin 5-HT3 receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 105826-92-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,8,2 and 6 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 105826-92:
(8*1)+(7*0)+(6*5)+(5*8)+(4*2)+(3*6)+(2*9)+(1*2)=124
124 % 10 = 4
So 105826-92-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H
