10583-67-2Relevant articles and documents
IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS
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, (2022/02/28)
Compounds are provided that assemble together in vivo to form an ASGPR-binding compound that has an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein.
Synthesis and characterization of monosaccharide derivatives and application of sugar-based prolinamides in asymmetric synthesis
Agarwal, Jyoti,Peddinti, Rama Krishna
, p. 6390 - 6406,17 (2020/09/16)
For the first time, the β-anomer of N-acetylglucosamine derivative methyl 2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside (9b) was synthesized, isolated, and used in the synthesis of sugar-based primary amine 4b. Sugar-based primary amine 5a, a
Use of N,O-dimethylhydroxylamine as an anomeric protecting group in carbohydrate synthesis
Dasgupta, Somnath,Nitz, Mark
, p. 1918 - 1921 (2011/06/24)
The N,O-dimethyloxyamine-N-glycosides are introducedas anomerically protected building blocks for carbohydrate synthesis. These N-glycosides are stable to a variety of protecting group manipulations including acylation, alkylation, silylation, and acetal formation. The alkoxyamine-N-glycosides can be cleaved selectively with N-chlorosuccinimide to give the desired hemiacetals in excellent yield. Furthermore, these Nglycosides are stable to the activation conditions required for glycosylation using thioglycoside and trichloroacetimidate glycosyl donors suggesting N,O-dialkoxyamine-N-glycosides will be useful for complex oligosaccharide synthesis.
