105859-17-4 Usage
General Description
1-(2,4-difluorophenyl)-6,8-difluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid is a chemical compound with the molecular formula C21H13F4N3O3. It is a quinolone carboxylic acid derivative and is commonly used as an antimicrobial agent in the treatment of bacterial infections. 1-(2,4-difluorophenyl)-6,8-difluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid works by inhibiting the DNA gyrase enzyme, which is essential for the replication and transcription of bacterial DNA. As a result, it prevents the growth and spread of bacterial cells, effectively treating the infection. Additionally, it has a broad spectrum of activity against various Gram-positive and Gram-negative bacteria, making it a versatile and widely used antibiotic in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 105859-17-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,8,5 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 105859-17:
(8*1)+(7*0)+(6*5)+(5*8)+(4*5)+(3*9)+(2*1)+(1*7)=134
134 % 10 = 4
So 105859-17-4 is a valid CAS Registry Number.
105859-17-4Relevant articles and documents
Synthesis and Structure-Activity Relationship of 1-Aryl-6,8-difluoroquinolone Antibacterial Agents
Chu, Daniel T. W.,Fernandes, Prabhavathi B.,Maleczka, Robert E.,Nordeen, Carl W.,Pernet, Andre G.
, p. 504 - 509 (2007/10/02)
A series of new arylfluoroquinolones has been prepared.These derivatives are characterized by having fluorine atoms at the 6- and 8-positions, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is 2,4-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(4-Fluorophenyl)-6,8-difluoro-7-piperazin-1-yl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (22) was found to possesss excellent in vitro potency and in vivo efficacy.
