105859-85-6

Basic information

• Product Name: Acetamide, N,N'-1,6-hexanediylbis[N-methyl-
• CAS NO: 105859-85-6
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Mol File: 105859-85-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N,N'-1,6-hexanediylbis[N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N,N'-1,6-hexanediylbis[N-methyl-(105859-85-6)
• EPA Substance Registry System: Acetamide, N,N'-1,6-hexanediylbis[N-methyl-(105859-85-6)

Safety Data

• Hazardous Substances Data: 105859-85-6(Hazardous Substances Data)

Upstream product

• 3073-59-4 hexamethylene bisacetamide 
• 74-88-4 methyl iodide 

Relevant articles and documents

Lead optimization of HMBA to develop potent HEXIM1 inducers

The potency of a series of Hexamethylene bis-acetamide (HMBA) derivatives inducing Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) was determined in LNCaP prostate cancer cells. Several compounds with unsymmetrical structures showed significantly improved activity. Distinct from HMBA, these analogs have increased hydrophobicity and can improve the short half-life of HMBA, which is one of the factors that have limited the application of HMBA in clinics. The unsymmetrical scaffolds of the new analogs provide the basis for further lead optimization of the compounds using combinatorial chemistry strategy.