1058705-57-9Relevant articles and documents
Novel potent apoA-I peptide mimetics that stimulate cholesterol efflux and pre-β particle formation in vitro
Ingenito, Raffaele,Burton, Charlotte,Langella, Annunziata,Chen, Xun,Zytko, Karolina,Pessi, Antonello,Wang, Jun,Bianchi, Elisabetta
supporting information; experimental part, p. 236 - 239 (2010/04/05)
Reverse cholesterol transport (RCT) is believed to be the primary mechanism by which HDL and its major protein apoA-I protect against atherosclerosis. Starting from the inactive 22-amino acid peptide representing the consensus sequence of the class A amphipathic helical repeats of apoA-I, we designed novel peptides able to mobilize cholesterol from macrophages in vitro, and to stimulate the formation of 'nascent HDL' particles, with potency comparable to the entire apoA-I protein.