1059153-44-4Relevant articles and documents
Stereocontrolled total synthesis of (-)-gleenol using Claisen rearrangement of sterically congested dihydropyran
Nakazaki, Atsuo,Era, Tomohiro,Kobayashi, Susumu
, p. 770 - 771 (2008/12/21)
A stereocontrolled total synthesis of enantiomerically pure (-)-gleenol using an improved substrate to construct the spiro[4.5]decane through Claisen rearrangement has been achieved. The most striking feature of this synthesis is that the rearrangement of sterically congested dihydropyran, bearing all requisite substituants with proper stereochemistry, afforded the fully functionalized spiro[4.5]decane in a single step. Copyright