1059172-55-2

Basic information

• Product Name: N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
• Synonyms: N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
• CAS NO: 1059172-55-2
• Molecular Weight: 368.801
• Mol File: 1059172-55-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine(1059172-55-2)
• EPA Substance Registry System: N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine(1059172-55-2)

Safety Data

• Hazardous Substances Data: 1059172-55-2(Hazardous Substances Data)

Upstream product

• 791644-48-9 2-chloro-5-fluoronicotinonitrile 
• 45743-05-3 2-chlorobenzimidamide 
• 1059172-57-4 2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-ol 
• 75302-64-6 2-chloro-5-fluoropyridine-3-carboxamide 
• 873-32-5 2-Chlorobenzonitrile 
• 82671-06-5 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid 
• 38186-88-8 2-chloro-5-fluoronicotinic acid 
• 404827-81-2 4-chloro-2-(2-chloro-phenyl)-5,6-dimethyl-pyrimidine 
• 1034667-22-5 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-amine 

Relevant articles and documents

AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

PROCESS FOR PREPARING 5-FLUORO-1H-PYRAZOLO [3, 4-B] PYRIDIN-3-AMINE AND DERIVATIVES THEREOF

The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo [3, 4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo [3, 4- b] ρyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof. Reagents and conditi ons : i. Pd ( OAc )2, PPh3, Et3N, H2CO2; i i. 1 ) (COCl )2, CH2Cl2, cat. DMF; 2 ) NH3 (g ), dioxane, i i i. TFAA, Et3N, CH2Cl2, O°C; iv. H2NNH2. H2O, n-butanol, reflux.