1059596-61-0

Basic information

• Product Name: N-Cbz-L-proline p-tolylthiol ester
• Synonyms: N-Cbz-L-proline p-tolylthiol ester
• CAS NO: 1059596-61-0
• Molecular Weight: 355.458
• Mol File: 1059596-61-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-Cbz-L-proline p-tolylthiol ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cbz-L-proline p-tolylthiol ester(1059596-61-0)
• EPA Substance Registry System: N-Cbz-L-proline p-tolylthiol ester(1059596-61-0)

Safety Data

• Hazardous Substances Data: 1059596-61-0(Hazardous Substances Data)

Upstream product

• 106-45-6 para-thiocresol 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 1059597-26-0 (S)-benzyl 2-(thiophene-5-carbonyl)pyrrolidine-1-carboxylate 
• 6686-03-9 (S)-benzyl 2-(((S)-3-(1H-indol-3-yl)-1-methoxy-1-oxopropan-2-yl)carbamoyl)pyrrolidine-1-carboxylate 
• 2873-37-2 -L-leucine methyl ester 
• 2766-31-6 ethyl (N-benzoxycarbonyl-L-prolyl)glycinate 
• 1310941-78-6 C₁₈H₂₄N₂O₆ 

Relevant articles and documents

HMDO-promoted peptide and protein synthesis in ionic liquids

Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63-94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.

Synthesis of high enantiopurity N-protected α-amino ketones by thiol ester-organostannane cross-coupling using pH-neutral conditions

(Chemical Equation Presented) An efficient synthesis of high enantiopurity N-protected α-amino ketones is described. Complementing other studies using boronic acids and thiol esters, this Cu(I) diphenylphosphinate (CuDPP)-mediated, palladium-catalyzed cou