105986-58-1Relevant articles and documents
Synthesis of the multisubstituted halogenated olefins via cross-coupling of dihaloalkenes with alkylzinc bromides
Andrei, Daniela,Wnuk, Stanislaw F.
, p. 405 - 408 (2007/10/03)
The 1-fluoro-1-haloalkenes undergo Pd-catalyzed Negishi cross-couplings with primary alkylzinc bromides to give multisubstituted fluoroalkenes. The alkylation was trans-selective giving pure Z-fluoroalkenes in most cases. The highest yields were obtained with Pd2(dba)3 and PdCl 2(dppb) catalysts but the best stereochemical outcome was obtained with less reactive Pd(PPh3)4. The tertiary alkylzincs also produced desired fluoroalkenes in high yields. Coupling of β,β- dichlorostyrene with organozinc reagent resulted in the formation of monocoupled product.
ALKYL-ALKENYL CROSS COUPLING VIA ALKYL COBALOXIME RADICAL CHEMISTRY. AN ALKYL EQUIVALENT TO THE HECK REACTION COMPATIBLE WITH COMMON ORGANIC FUNCTIONAL GROUPS
Branchaud, Bruce P.,Meier, Mark S.,Choi, Youngshin
, p. 167 - 170 (2007/10/02)
A novel cobalt-mediated radical-olefin coupling reaction is described which regenerates the olefin functionality in the final product.The regeneration of olefin functionality is unique among radical-olefin couplings using simple activated alkenes.