106023-62-5

Basic information

• Product Name: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]
• CAS NO: 106023-62-5
• Molecular Formula: C39H49N6O6P
• Molecular Weight: 728.828
• Mol File: 106023-62-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite](CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite](106023-62-5)
• EPA Substance Registry System: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite](106023-62-5)

Safety Data

• Hazardous Substances Data: 106023-62-5(Hazardous Substances Data)

Upstream product

• 2002-35-9 N-6-methyl-2'-deoxyribofuranosil adenine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 92611-10-4 bis(N,N-diisopropylamino)methoxyphosphine 
• 98056-69-0 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-methyladenosine 

Relevant articles and documents

Synthesis and Properties of Phosphoramidite Derivatives of Modified Nucleosides

Protected N6-methyl-2'-deoxyadenosine (d-m6A), 2-amino-2'-deoxyadenosine (d-a2A), 2'-deoxyinosine (dI), 5-methyl-2'-deoxycytidine (d-m5C) and deoxyuridine (dU) were reacted with bis(diisopropylamino)methoxyphosphine in the presence of diisopropylammonium tetrazolide as the activating reagent to give the corresponding phosphoramidite derivatives in yields of 100, 65, 90, 78 and 65 percent respectively.The 31P-nuclear magnetic resonance spectra of the products were measured.Using these compounds, dinucleotides and trinucleotides were synthesized on a longchain alkylamine controlled pore glass (LCA-CPG) in quantitative yields.The stability of 6-methyldeoxyadenosine and N,N-diisobutyryl-2-aminodeoxyadenosine to acid was examined.When protected di- and trinucleotides (m6A-T, a2A-T, T-m6A-T, T-a2A-T) bound to the support (LCA-CPG) were treated with 3 percent trichloroacetic acid in dichloromethane, depurination was negligible within 10 min (dinucleotide) or 60 min (trinucleotide).Keywords - phosphoramidite; solid-phase synthesis; phosphite method; acid treatment; enzyme degradation