106046-95-1Relevant articles and documents
Biarylhydrazine compounds and their adducts and applications in the preparation of antitumor drugs
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Paragraph 0058; 0064; 0065; 0131-0135, (2022/03/27)
The present invention discloses a biarylhydrazine compound and its application in the preparation of antitumor drugs, the structure of the arylhydrazine compound as shown in formula I, the adduct is a biarylhydrazine compound on the hydrazine group plus benzyloxycarbonyl glycyl prolyl. The anticancer activity of the biarylhydrazine compounds of the present invention is superior to that of the existing positive control drug procarbazine; its Z-GP adduct can significantly reduce in vitro toxicity and in vivo toxicity to normal cells, and can be excised by FΑP-α enzyme specific hydrolysis in vivo (Z-GP) to release hydrolysate products; its Z-GP adduct can significantly inhibit tumor growth in tumor-bearing nude mice and reduce toxicity to non-target organs.
Nickel-catalyzed N-arylation of benzophenone hydrazone with bromoarenes
Wu, Wei,Fan, Xin-Heng,Zhang, Li-Peng,Yang, Lian-Ming
, p. 3364 - 3367 (2014/01/06)
A nickel-catalyzed method for the cross-coupling of benzophenone hydrazone with aryl bromides is described. The use of a simple Ni(ii)/NHC catalyst leads to the arylated hydrazones in good or acceptable yields. This protocol provides a simple, convenient alternative to the synthesis of arylhydrazines.
A palladium-catalyzed method for the preparation of indoles via the Fischer indole synthesis
Wagaw, Seble,Yang, Bryant H.,Buchwald, Stephen L.
, p. 10251 - 10263 (2007/10/03)
A Pd-catalyzed method for the preparation of N-aryl benzophenone hydrazones 4 is described. The use of a Pd/BINAP-based catalyst provides hydrazones 4 in good yields. Using 0.1 mol % of a Pd/9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (Xantphos) cata
