106047-29-4Relevant articles and documents
NOVEL COMPOUND WITH ELECTRON INJECTION AND/OR ELECTRON TRANSPORT CAPABILITIES AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
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Paragraph 0115; 0120; 0133, (2018/06/15)
A compound represented by Formula 1 below and an organic light-emitting device including the compound are provided: Formula 1 Substituents in Formula 1 are the same as defined in the specification.
Organic light emitting device containing polycyclic heteroaryl compounds
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Page/Page column 21, (2011/04/14)
A heterocyclic compound of general formula (1), an organic light-emitting device including the heterocyclic compound,and a flat panel display device including the organic light-emitting device are provided. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltage, high luminance and long lifespan: in which for example R4, R5, R6, R7, R8, R10 and R11 are hydrogen atoms, R1 and R9 are non-hydrogen substituent, and R2 and R3 are selected from methyl and phenyl groups.
SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells
Bonnet, Muriel,Flanagan, Jack U.,Chan, Denise A.,Lai, Edwin W.,Nguyen, Phuong,Giaccia, Amato J.,Hay, Michael P.
supporting information; experimental part, p. 3347 - 3356 (2011/07/09)
We recently identified a class of pyridyl aniline thiazoles (PAT) that displayed selective cytotoxicity for von Hippel-Lindau (VHL) deficient renal cell carcinoma (RCC) cells in vitro and in vivo. Structure-activity relationship (SAR) studies were used to develop a comparative molecular field analysis (CoMFA) model that related VHL-selective potency to the three-dimensional arrangement of chemical features of the chemotype. We now report the further molecular alignment-guided exploration of the chemotype to discover potent and selective PAT analogues. The contribution of the central thiazole ring was explored using a series of five- and six-membered ring heterocyclic replacements to vary the electronic and steric interactions in the central unit. We also explored a positive steric CoMFA contour adjacent to the pyridyl ring using Pd-catalysed cross-coupling Suzuki-Miyaura, Sonogashira and nucleophilic displacement reactions to prepare of a series of aryl-, alkynyl-, alkoxy- and alkylamino-substituted pyridines, respectively. In vitro potency and selectivity were determined using paired RCC cell lines: the VHL-null cell line RCC4 and the VHL-positive cell line RCC4-VHL. Active analogues selectively induced autophagy in RCC4 cells. We have used the new SAR data to further develop the CoMFA model, and compared this to a 2D-QSAR method. Our progress towards realising the therapeutic potential of this chemotype as a targeted cytotoxic therapy for the treatment of RCC by exploiting the absence of the VHL tumour suppressor gene is reported.