106058-73-5Relevant articles and documents
Water-mediated, green, and efficient synthesis of bisquinolones under catalyst-free conditions
Madhu, Bandi,Reddy, Ch. Venkata Ramana,Dubey, Pramod Kumar
, p. 421 - 427 (2017)
Water-mediated, green, and efficient synthesis involving condensation of 4-hydroxy-1-methylquinoline-2(1H)-one (3) with different aromatic and heterocyclic aldehydes (4a–n) leading to 3,3′-(arylmethylene)-bis-(4-hydroxy-1-methylquinolin-2(1H)-one) 5(a–n) under catalyst-free conditions is described. This reaction has an easy workup without using column chromatography and provides excellent yields of the products in shorter reaction times. It does not require any catalyst and uses water as the medium which is the greenest solvent. 3 required in this work was itself obtained by condensation of N-methylaniline (1) with malonic acid (2) in the presence of POCl3using a previously reported procedure.
Synthesis of SF2809-V, chymase inhibitor, and its analogs by three component reaction: Model study for high throughput synthesis of a chymase inhibitor library
Yamamoto, Yasuo,Harimaya, Kenzo
, p. 238 - 239 (2004)
SF2809-V, chymase inhibitor, was synthesized by a three component reaction and its sixteen analogs were also synthesized to establish a method for preparation of a chymase inhibitor library.
DBU Acetate Mediated: One-pot Multi Component Syntheses of Dihydropyrano[3,2-c]quinolones
Bhupathi, Rajasekar,Madhu, Bandi,Devi, B. Rama,Reddy, Ch. Venkata Ramana,Dubey
, p. 1911 - 1916 (2016)
Three-component reaction involving condensation of 1-methylquinoline-2,4(1H,3H)-dione(1), aromatic aldehydes (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h) and malononitrile/cyanoaceticester (3a, 3b) in{(1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate)}[DBU][Ac] as ta
