106064-33-9

Basic information

• Product Name: Pentanoic acid, 3-oxo-5-(phenylmethoxy)-, 2-methylpropyl ester
• CAS NO: 106064-33-9
• Molecular Formula: C16H22O4
• Molecular Weight: 278.348
• Mol File: 106064-33-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pentanoic acid, 3-oxo-5-(phenylmethoxy)-, 2-methylpropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 3-oxo-5-(phenylmethoxy)-, 2-methylpropyl ester(106064-33-9)
• EPA Substance Registry System: Pentanoic acid, 3-oxo-5-(phenylmethoxy)-, 2-methylpropyl ester(106064-33-9)

Safety Data

• Hazardous Substances Data: 106064-33-9(Hazardous Substances Data)

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 7779-75-1 isobutyl acetoacetate 

Downstream Products

• 106064-44-2 isobutyl (3S)-5-benzyloxy-3-hydroxypentanoate 
• 912805-56-2 isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate 
• 198754-78-8 (3S)-5-benzyloxy-3-(tert-butyldimethylsilyl)oxypentanal 
• 221627-46-9 (3R,4S,6S)-8-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-3-methyl-oct-1-en-4-ol 
• 221627-48-1 (3S,4R,6S)-8-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-3-methyl-oct-1-en-4-ol 
• 221627-27-6 (3S,5R,6S)-1-Benzyloxy-6-methyl-5-triisopropylsilanyloxy-oct-7-en-3-ol 
• 221627-25-4 (3S,5S,6R)-1-Benzyloxy-6-methyl-5-triisopropylsilanyloxy-oct-7-en-3-ol 
• 221627-50-5 [(3S,5S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-5-triisopropylsilanyloxy-oct-7-enyloxymethyl]-benzene 
• 221627-52-7 [(3S,5R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-5-triisopropylsilanyloxy-oct-7-enyloxymethyl]-benzene 
• 88818-17-1 (R)-1-phenylmethoxyoct-7-en-3-ol 
• 106064-55-5 Methanesulfonic acid (S)-1-allyl-5-benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-pentyl ester 
• 106064-50-0 5-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid isobutyl ester 
• 106064-57-7 [(S)-1-(2-Benzyloxy-ethyl)-3-iodo-hex-5-enyloxy]-tert-butyl-diphenyl-silane 
• 106064-53-3 8-(benzyloxy)-6-((tert-butyldiphenylsilyl)oxy)-4-hydroxy-1-octene 

Relevant articles and documents

Synthetic studies of complex immunostimulants from Quillaja saponaria: Synthesis of the potent clinical immunoadjuvant QS-21Aapi

QS-21 is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing vaccine therapy clinical trials involving QS-21 as a critical adjuvant component for immune response augmentation. QS-21 is a natural product immunostimulatory adjuvant, eliciting both T-cell- and antibody-mediated immune responses with microgram doses. Herein is reported the synthesis of QS-21 Aapi in a highly modular strategy, applying novel glycosylation methodologies to a convergent construction of the potent saponin immunostimulant. The chemical synthesis of QS-21 offers unique opportunities to probe its mode of biological action through the preparation of otherwise unattainable nonnatural saponin analogues.