1061223-45-7 Usage
Description
(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid is an organic compound characterized by the presence of a boron atom bonded to a phenyl ring with a fluorine atom at the 4-position and a hydroxymethyl group at the 2-position. This unique structure endows it with specific chemical properties and reactivity, making it a valuable intermediate in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid is used as a key intermediate in the synthesis of 4,5-dihydro-1H-pyrazole derivatives, which are known as cholesterol 24 hydroxylase inhibitors. Cholesterol 24 hydroxylase is an enzyme involved in the regulation of cholesterol homeostasis, and its inhibition can lead to potential therapeutic benefits in the treatment of various cholesterol-related disorders, such as atherosclerosis and hypercholesterolemia.
In the synthesis process, (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid can undergo Suzuki-Miyaura cross-coupling reactions with appropriate halide or triflate precursors to form the desired 4,5-dihydro-1H-pyrazole derivatives. This method allows for the formation of carbon-carbon bonds, which are crucial for the construction of the target molecule's structure.
Furthermore, the boronic acid moiety in (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid can also participate in other types of reactions, such as oxidation, hydrolysis, or esterification, which can lead to the formation of additional functional groups or derivatives with potential applications in various fields, including materials science, agrochemistry, and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1061223-45-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,1,2,2 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1061223-45:
(9*1)+(8*0)+(7*6)+(6*1)+(5*2)+(4*2)+(3*3)+(2*4)+(1*5)=97
97 % 10 = 7
So 1061223-45-7 is a valid CAS Registry Number.
1061223-45-7Relevant articles and documents
NOVEL PROCESS FOR THE PREPARATION OF TAVABOROLE, ITS NOVEL POLYMORPHIC FORMS AND THE POLYMORPHS THEREOF
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Page/Page column 33; 34, (2017/11/15)
The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for preparation of those polymorphic forms. The invention also relates to process for purification of Tavaborole to obtain the Tavaborole in significantly high yield and substantially pure form.
