1062118-24-4Relevant articles and documents
Asymmetric organocatalysis: An efficient enantioselective access to benzopyranes and chromenes
Rueping, Magnus,Sugiono, Erli,Merino, Estibaliz
supporting information; experimental part, p. 6329 - 6332 (2009/06/23)
A method was proposed for the development of diaryl prolinol by catalyzed and enatioselective reaction of diketones with α,β-unsaturated aldehydes to produce biologically active chromenones. The study found that the reaction of α-β-unsaturated aldehydes with a chiral secondary amine can produce an intermediary iminium ion. The study observed that catalysis of the transformation can be achieved and the chromenone can be isolated in good yields. The study also observed that the enantioselective addition-cyclization cascade reaction of diketone with aldehyde and 10 mol% of dyarylprolinol catalyst can produce the 2-hydroxychromenone in a yield of 78%. The organocatalytic addition-acetalization reaction can be used to produce 2-hydroxychromenones with different aliphatic and aromatic substituents.
