1062512-49-5Relevant articles and documents
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase
Keith, John M.,Apodaca, Richard,Xiao, Wei,Seierstad, Mark,Pattabiraman, Kanaka,Wu, Jiejun,Webb, Michael,Karbarz, Mark J.,Brown, Sean,Wilson, Sandy,Scott, Brian,Tham, Chui-Se,Luo, Lin,Palmer, James,Wennerholm, Michelle,Chaplan, Sandra,Breitenbucher, J. Guy
scheme or table, p. 4838 - 4843 (2009/05/07)
A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are