1062639-48-8

Basic information

• Product Name: 2,2-dimethyl-3-(4-phenyl-1H-1,2,3-triazol-1-yl)-2,3-dihydronaphtho[1,2-b]furan-4,5-dione
• Synonyms: 2,2-dimethyl-3-(4-phenyl-1H-1,2,3-triazol-1-yl)-2,3-dihydronaphtho[1,2-b]furan-4,5-dione
• CAS NO: 1062639-48-8
• Molecular Weight: 371.395
• Mol File: 1062639-48-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-3-(4-phenyl-1H-1,2,3-triazol-1-yl)-2,3-dihydronaphtho[1,2-b]furan-4,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-3-(4-phenyl-1H-1,2,3-triazol-1-yl)-2,3-dihydronaphtho[1,2-b]furan-4,5-dione(1062639-48-8)
• EPA Substance Registry System: 2,2-dimethyl-3-(4-phenyl-1H-1,2,3-triazol-1-yl)-2,3-dihydronaphtho[1,2-b]furan-4,5-dione(1062639-48-8)

Safety Data

• Hazardous Substances Data: 1062639-48-8(Hazardous Substances Data)

Upstream product

• 84-79-7 Lapachol 
• 15297-99-1 nor-lapachol 
• 1062639-43-3 3-azido-2,2-dimethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione, 3-azido-nor-β-lapachone 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Design, synthesis, and biological evaluation of 3-(1-benzotriazole)-nor-β-lapachones as NQO1-directed antitumor agents

A series of novel 3-(1-benzotriazole)-nor-β-lapachones 5a–5l were synthesized as the NQO1-targeted anticancer agents. Most of these compounds displayed good antiproliferative activity against the breast cancer MCF-7, lung cancer A549 and hepatocellular ca

On the search for potential antimycobacterial drugs: Synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis

Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values ≤ 6.25 μg mL-1. These substances are promising antimycobacterial prototypes.

A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones

Several studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering nor-β-lapachone as an important prototype, a set of new 3-substituted nor-β-lapachones was synthesized by a new synthetic route that involves the use of synthetic intermediate generated for coupling with several nucleophiles containing the carbohydrate and 2H-pyrazole substituent moieties. All the compounds were screened against four tumor cell lines. Two of the compounds showed moderate cytotoxicity, while the other compounds strongly inhibit all tested cancer cell lines.