106429-08-7Relevant articles and documents
D-578, an orally active triple monoamine reuptake inhibitor, displays antidepressant and anti-PTSD like effects in rats
Dutta, Aloke K.,Santra, Soumava,Harutyunyan,Das, Banibrata,Lisieski, Michael J.,Xu, Liping,Antonio, Tamara,Reith, Maarten E.A.,Perrine, Shane A.
, (2019/09/10)
Significant unmet needs exist for development of better pharmacotherapeutic agents for major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) as the current drugs are inadequate. Our goal in this study is to investigate behavioral pharm
Benzothiazole based inhibitors of p38α MAP kinase
Liu, Chunjian,Lin, James,Pitt, Sidney,Zhang, Rosemary F.,Sack, John S.,Kiefer, Susan E.,Kish, Kevin,Doweyko, Arthur M.,Zhang, Hongjian,Marathe, Punit H.,Trzaskos, James,Mckinnon, Murray,Dodd, John H.,Barrish, Joel C.,Schieven, Gary L.,Leftheris, Katerina
, p. 1874 - 1879 (2008/12/21)
Rational design, synthesis, and SAR studies of a novel class of benzothiazole based inhibitors of p38α MAP kinase are described. The issue of metabolic instability associated with vicinal phenyl, benzo[d]thiazol-6-yl oxazoles/imidazoles was addressed by t
BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KIANSE
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