106429-59-8

Basic information

• Product Name: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI)
• Synonyms: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI);2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-5-carbaldehyde;2,3-Dihydro-2-oxo-1H-benzimidazole-5-carboxaldehyde;1H-BenziMidazole-5-carboxaldehyde, 2,3-dihydro-2-oxo-;2,3-Dihydro-2-oxo-1H-benzo[d]imidazol-5-carbaldehyde;2-OXO-2,3-DIHYDRO-1H-1,3-BENZODIAZOLE-5-CARBALDEHYDE;2-oxo-1,3-dihydrobenzimidazole-5-carbaldehyde
• CAS NO: 106429-59-8
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.14544
• Product Categories: BENZIMIDAZOLE
• Mol File: 106429-59-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 194℃
• Flash Point: 81℃
• Appearance: /
• Density: 1.365
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
• PKA: 11.66±0.30(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI)(106429-59-8)
• EPA Substance Registry System: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI)(106429-59-8)

Safety Data

• Hazardous Substances Data: 106429-59-8(Hazardous Substances Data)

Usage

Description

1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI) is an organic compound with the molecular formula C8H6N2O2. It is a derivative of benzimidazole, a heterocyclic compound consisting of a benzene ring fused to an imidazole ring. The compound features a carboxaldehyde group at the 5-position, a double bond at the 2-position, and a hydrogen atom at the 1-position. This structure endows it with unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of novel drugs with potential therapeutic applications.
Used in Nuclease Inhibitors:
1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI) is used as a precursor in the preparation of nuclease inhibitors. These inhibitors are useful in the treatment and prophylaxis of diseases where nuclease activity plays a role, such as certain types of cancer or viral infections. By inhibiting nucleases, these compounds can help regulate cellular processes and potentially prevent or slow down disease progression.

Upstream product

• 221289-88-9 2-hydroxybenzimidazole-5-carbonitrile 
• 17626-40-3 4-cyano-1,2-phenylenediamine 
• 1313-13-9 manganese dioxide 
• 106429-58-7 5-hydroxymethyl-1,3-dihydro-benzoimidazol-2-one 
• 221289-88-9 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile 
• 1575-37-7 4-Bromo-benzene-1,2-diamine 
• 39513-26-3 5-bromo-1,3-dihydro-benzoimidazol-2-one 

Downstream Products

• 288579-82-8 5-formyl-2-chlorobenzimidazole 

Relevant articles and documents

POLYCYCLIC AMINES AS OPIOID RECEPTOR MODULATORS

The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

2'-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

5-Phenylterbenzimidazole (1) is active as a topoisomerase I poison (topo I) and is cytotoxic to human tumor cells. No cross-resistance was observed for 1 when it was evaluated against the camptothecin-resistant cell line, CPT-K5. Derivatives of 1 substituted at the 2'-position, however, did exhibit cross-resistance to this cell line. The basis for the resistance of this cell line towards CPT is that it possesses a mutant form of topo I. These results suggest that substituents at the 2'-position may be in proximity to the wild-type enzyme. Therefore, we hypothesized that terbenzimidazoles with 2'-substituents could be capable of interacting with the enzyme and thereby influence activity within this class of topo I poisons. 5-Phenylterbenzimidazoles with a hydroxy, hydroxymethyl, mercapto, amino, N-benzoylaminomethyl, chloro, and trifluoromethyl group at the 2'-position were synthesized. In addition, several 2'-ethyl-5-phenylterbenzimidazoles were prepared containing either a methoxy, hydroxy, amino, or N-acetylamino group at the 2-position of the ethyl side-chain. These 2'-substituted 5-phenylterbenzimidazoles were evaluated as topo I poisons and for cytotoxic activity. The presence of a strong electron-withdrawing group at the 2'-position, such as a chloro or trifluoromethyl group, did enhance both topo I poisoning activity and cytotoxicity. Studies on the relative DNA binding affinity of 1 to its 2'-amino and 2'-trifluoromethyl derivatives did exhibit a correlation with their relative differences in biological activity. Copyright (C) 2000 Elsevier Science Ltd.