106475-19-8

Basic information

• Product Name: 1,1'-Biphenyl, 4'-bromo-2-methyl-
• CAS NO: 106475-19-8
• Molecular Formula: C13H11Br
• Molecular Weight: 247.134
• Mol File: 106475-19-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,1'-Biphenyl, 4'-bromo-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-Biphenyl, 4'-bromo-2-methyl-(106475-19-8)
• EPA Substance Registry System: 1,1'-Biphenyl, 4'-bromo-2-methyl-(106475-19-8)

Safety Data

• Hazardous Substances Data: 106475-19-8(Hazardous Substances Data)

Usage

Structure

Substituted biphenyl with a bromine and a methyl group attached to the 4' position of one of the benzene rings

Applications

a. Research and development of pharmaceuticals
b. Production of dyes and pigments
c. Potential use in organic light-emitting diodes (OLEDs) and other electronic applications

Toxicity

Low toxicity, but proper safety protocols should be followed when handling

Safety

Handle with care and follow proper safety protocols

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 66107-30-0 4-bromophenyl trifluoromethanesulfonate 
• 673-40-5 4-bromobenzenediazonium tetrafluoroborate 
• 108-88-3 toluene 
• 589-87-7 1,4-bromoiodobenzene 
• 16419-60-6 2-Methylphenylboronic acid 
• 7029-31-4 bis(2-methylphenyl)zinc 
• 201230-82-2 carbon monoxide 
• 53034-21-2 α-(4-bromophenylazo)triphenylmethane 

Downstream Products

• 491595-36-9 (2'-methyl-[1,1'-biphenyl]-4-yl)boronic acid 
• 643-58-3 2-methylbiphenyl 

Relevant articles and documents

Generation of Aryl Radicals by the Oxidation of α-(Arylazo)triphenylmethanes by Cerium(IV) Ammonium Nitrate

The one-electron oxidation of α-(arylazo)triphenylmethanes by cerium(IV) ammonium nitrate (CAN) generated aryl radicals along with the triphenylmethyl cation.When the reaction was carried out in the presence of appropriate radical-trapping agents, such as arenes and olefins, the corresponding addition products were obtained in moderate yield.The oxidation of the arylazo compounds with CAN was accelerated by the addition of acids.

Control of reactive site in Palladium-Catalyzed grignard Cross-Coupling of arenes containing both bromide and triflate

Reaction of 4-bromophenyl triflate (1) with phenylmagnesium bromide in the presence of 5 mol % of PdCl2(dppp) gave 97% yield of 4-bromobiphenyl (2a), which was formed by selective replacement of triflate in 1 by phenyl. On the other hand, bromide in 1 was substituted with the phenyl Grignard reagent selectively by use of PdCl2(meo-mop)2 to give 4-biphenyl triflate (3a) in high yield. The selective substitution was demonstrated to take place at the oxidative addition step to a palladium(0) species in a stoichiometric reaction of 1 with palladium(0) phosphine complexes.

CRYSTALLINE AND SALT FORMS OF AN ORGANIC COMPOUND AND PHARMACEUTICAL COMPOSITIONS THEREOF

Provided herein are various salts, including tris(hydroxymethyl)aminomethane salts and sodium salts, as well as various crystalline forms of the compound represented by the structural formula: Also provided are pharmaceutical compositions comprising these salts and crystalline forms, methods for their manufacture, and uses thereof for treating conditions, including but not limited to conditions that would benefit from inhibition of dihydroorotate dehydrogenase (DHODH).

Palladium-imidazolium-catalyzed carbonylative coupling of aryl diazonium ions and aryl boronic acids

Palladium(II) acetate and N,N-bis-(2,6-diisopropylphenyl)dihydroimidazolium chloride (2 mol%) were used to catalyze the carbonylative coupling of aryl diazonium tetrafluoroborate salts and aryl boronic acids to form aryl ketones. Optimal conditions includ