106582-41-6 Usage
Description
7-CHLORO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE is an organic compound characterized by its unique molecular structure, featuring a naphthyridine ring with a chlorine atom at the 7th position and two trifluoromethyl groups at the 2nd and 4th positions. 7-CHLORO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE is known for its potential applications in the pharmaceutical industry, particularly in the synthesis of various drug molecules.
Uses
Used in Pharmaceutical Industry:
7-CHLORO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE is used as a reactant for the preparation of 2-amino-(4-tropinyl)quinolines, which are known as CXCR3 antagonists. These antagonists play a crucial role in modulating the immune response and have potential applications in treating various immune-mediated diseases and conditions.
In the synthesis of 2-amino-(4-tropinyl)quinolines, 7-CHLORO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE serves as a key intermediate, contributing to the development of novel therapeutic agents with improved efficacy and safety profiles. The compound's unique structural features enable the formation of specific interactions with target proteins, making it a valuable component in the design and synthesis of CXCR3 antagonists.
Check Digit Verification of cas no
The CAS Registry Mumber 106582-41-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,5,8 and 2 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 106582-41:
(8*1)+(7*0)+(6*6)+(5*5)+(4*8)+(3*2)+(2*4)+(1*1)=116
116 % 10 = 6
So 106582-41-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H3ClF6N2/c11-7-2-1-4-5(9(12,13)14)3-6(10(15,16)17)18-8(4)19-7/h1-3H
106582-41-6Relevant articles and documents
Polymorphic equilibrium responsive thermal and mechanical stimuli in light-emitting crystals of N -methylaminonaphthyridine
Harada, Naomi,Abe, Yuichiro,Karasawa, Satoru,Koga, Noboru
, p. 6282 - 6285 (2012)
Crystal polymorphs of 1,8-naphthyridine derivative, being anti and syn conformers, show a reversible transformation from anti to syn by heating and from syn to anti by grinding with the alteration of emittance intensity, and notably, thermal transformation from anti to syn conformer took place in single-crystal-to-single-crystal (SC-to-SC) form, which was confirmed by a single crystal X-ray crystallography.
