1066-17-7 Usage
Description
Colistin, also known as Polymyxin E, is a complex of closely related cyclic peptides E1 and E2, along with minor analogues. It is produced by Bacillus polymyxa var. colistinus and is characterized by its highly basic nature and the incorporation of the unusual amino acid, diaminobutyric acid. The macrocyclic structure is completed through head-to-tail coupling of lysine, and it is balanced by a hydrophobic tail with short-chain fatty acids. Colistin is a broad-spectrum antibiotic that is particularly effective against Gram-negative bacteria, with its mechanism of action involving the disruption of the bacterial outer membrane through a detergent-like effect.
Uses
Used in Pharmaceutical Industry:
Colistin is used as an antibiotic for the treatment of severe Gram-negative bacterial infections that are resistant to other antibiotics. Its broad-spectrum activity and ability to target multidrug-resistant bacteria make it a valuable option in the fight against antibiotic-resistant infections.
Used in Hospital Settings:
In hospitals and other healthcare facilities, Colistin is used as a last-resort antibiotic for patients with life-threatening infections caused by Gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, which have developed resistance to other available treatments.
Brand Name:
Colistin is available under the brand name Coly-Mycin (Monarch).
Neurotoxicity and Nephrotoxicity
Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
Check Digit Verification of cas no
The CAS Registry Mumber 1066-17-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,6 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1066-17:
(6*1)+(5*0)+(4*6)+(3*6)+(2*1)+(1*7)=57
57 % 10 = 7
So 1066-17-7 is a valid CAS Registry Number.
InChI:InChI=1/C53H100N16O13/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+/m1/s1
