1067230-84-5

Basic information

• Product Name: [(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate
• Synonyms: [(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate
• CAS NO: 1067230-84-5
• Molecular Weight: 272.322
• Mol File: 1067230-84-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 421.1±25.0 °C(Predicted)
• Density: 1.246±0.06 g/cm3(Predicted)
• CAS DataBase Reference: [(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate(1067230-84-5)
• EPA Substance Registry System: [(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate(1067230-84-5)

Safety Data

• Hazardous Substances Data: 1067230-84-5(Hazardous Substances Data)

Usage

Description

[(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate is a sulfonate ester that features a dioxane ring and is derived from the esterification of 4-methylbenzenesulfonic acid with (2R)-1,4-dioxan-2-ol. This chemical compound is significant in the fields of medicinal and pharmaceutical chemistry, as it serves as a key intermediate in the synthesis of various biologically active molecules.

Uses

Used in Organic Synthesis:
[(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate is utilized as a reagent in organic synthesis, where it aids in the formation of complex organic compounds through chemical reactions.
Used as a Protecting Group for Alcohols:
In organic chemistry, this compound is employed as a protecting group for alcohols. It helps to shield the alcohol functional group during chemical reactions, preventing unwanted side reactions and ensuring the desired product is formed.
Used in Pharmaceutical Compound Synthesis:
[(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate acts as a precursor in the synthesis of pharmaceutical compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
[(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate is also used as a precursor for the synthesis of agrochemicals, which are chemicals specifically designed for use in agriculture to enhance crop protection and productivity.
Used in Medicinal Chemistry:
[(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate is important in medicinal chemistry due to its role in the synthesis of biologically active molecules, which can be further developed into potential therapeutic agents for various medical conditions.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 406913-93-7 [(2S)-1,4-dioxan-2-yl]methanol 

Downstream Products

• 2243162-67-4 C₁₉H₂₁N₃O₆S 
• 1112169-52-4 6-(2-(((S)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-N-(3-chloro-4-fluoro-benzyl)-2-methyl-pyrimidine-4-carboxamide 
• 1112169-54-6 6-(2-(((S)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-N-(4-fluoro-3-(2-hydroxy-ethoxy)-benzyl)-2-methyl-pyrimidine-4-carboxamide 
• 1112169-50-2 6-(2-(((S)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-N-(4-fluoro-3-methoxybenzyl)-2-methyl-pyrimidine-4-carboxamide 
• 1112169-48-8 6-(2-(((S)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-N-(3-methoxybenzyl)-2-methyl-pyrimidine-4-carboxamide 

Relevant articles and documents

2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS

Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

CRYSTAL FORM OF TRICYCLIC COMPOUNDS AND APPLICATION THEREOF

本發明公開了式(I)所示化合物的A晶型及B晶型，及其在製備治療HBV相關疾病藥物中的應用。 The invention discloses “A”crystal form and“B”crystal form of a compound represented by formula (I) and an application thereof in a preparation of a medicament for treating HBV-related diseases.

Heterocylic antiviral compounds

This invention relates to piperidine derivatives of formula I wherein R1, R2, R3 and R4 are as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 re