106746-76-3

Basic information

• Product Name: Benzenamine, 2-[[(5-methyl-1H-benzimidazol-2-yl)thio]methyl]-
• CAS NO: 106746-76-3
• Molecular Formula: C15H15N3S
• Molecular Weight: 269.37
• Mol File: 106746-76-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenamine, 2-[[(5-methyl-1H-benzimidazol-2-yl)thio]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-[[(5-methyl-1H-benzimidazol-2-yl)thio]methyl]-(106746-76-3)
• EPA Substance Registry System: Benzenamine, 2-[[(5-methyl-1H-benzimidazol-2-yl)thio]methyl]-(106746-76-3)

Safety Data

• Hazardous Substances Data: 106746-76-3(Hazardous Substances Data)

Upstream product

• 114059-99-3 ortho-(chloromethyl)-aniline 
• 27231-36-3 5-methyl-1H-benzoimidazole-2-thiol 

Downstream Products

• 106747-21-1 2-[[(5-methyl-1H-benzimidazol-2-yl)sulfinyl]-methyl]benzenamine 

Relevant articles and documents

Substituted 2-anilines as Potential Inhibitors of H+/K+ ATPase

A series of substituted 2-anilines were synthesized as potential inhibitors of the acid secretory enzyme H+/K+ ATPase.Substitutions on the aniline nitrogen atom resulted in potent enzyme inhibition in vitro but weak activity in gastric fistula dogs.Electron-donating substituents on the aniline ring enhanced in vitro and in vivo potency relative to the unubstituted analogue.The potency showed a correlation to the calculated pKa of the aniline nitrogen atom.Substitutions on the aniline and benzimidazole rings did not further enhance potency.Di- and trisubstituted aniline derivatives were potent inhibitors of the enzyme system.The preferred combination of substituents were a methoxy group on the benzimidazole ring and a single alkyl group on the aniline ring.One such compound, 76, was an effective inhibitor of acid secretion in the dog and was selected for further pharmacological study.