106759-13-1Relevant articles and documents
Epimerization of C-22 in (25R)- and (25S)-sapogenins
Vi?as-Bravo, Omar,Merino-Montiel, Penélope,Romero-López, Anabel,Montiel-Smith, Sara,Meza-Reyes, Socorro,Meléndez, Francisco J.,Sandoval-Ramírez, Jesús
, p. 60 - 67 (2014)
Most of the naturally occurring steroidal sapogenins (C-23 non-substituted frameworks), possess an R configuration at the spiro C-22 center. Their C-22 epimers have become important targets in biological research. This paper describes a procedure to obtain 22S-spirostans from 22R-sapogenins and pseudosapogenin skeletons, without affecting the chirality at either C-25 or C-20. An optimal way to synthesize the pair of C-22 stereoisomers of 23-acetyldiosgenin is also reported. The latter was obtained from a 22,26-epoxycholestane or from 23-acetylfurostene compounds.
Epimerization of C-22 in (25R)- and (25S)-sapogenins
Vias-Bravo, Omar,Merino-Montiel, Penlope,Romero-Lpez, Anabel,Montiel-Smith, Sara,Meza-Reyes, Socorro,Melndez, Francisco J.,Sandoval-Ramrez, Jess
, p. 60 - 67 (2015/01/30)
Most of the naturally occurring steroidal sapogenins (C-23 non-substituted frameworks), possess an R configuration at the spiro C-22 center. Their C-22 epimers have become important targets in biological research. This paper describes a procedure to obtain 22S-spirostans from 22R-sapogenins and pseudosapogenin skeletons, without affecting the chirality at either C-25 or C-20. An optimal way to synthesize the pair of C-22 stereoisomers of 23-acetyldiosgenin is also reported. The latter was obtained from a 22,26-epoxycholestane or from 23-acetylfurostene compounds.
Steroidal sapogenins from rhizomes of Yucca gloriosa
Skhirtladze,Benidze,Sulakvelidze
, p. 357 - 358 (2008/02/01)
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