1067647-39-5 Usage
Description
(R)-3-butanamidobutanoic acid tert-butyl ester, also known as (R)-3-Aminobutyric acid tert-butyl ester, is an organic compound with the molecular formula C9H19NO2. It is a tert-butyl ester derivative of the amino acid 3-aminobutyric acid and is characterized by its chiral structure and specific rotation of +20.1°. (R)-3-butanamidobutanoic acid tert-butyl ester is widely utilized in pharmaceutical and research applications, serving as a chiral building block in organic synthesis.
Uses
Used in Pharmaceutical Applications:
(R)-3-butanamidobutanoic acid tert-butyl ester is used as a chiral building block for the synthesis of various pharmaceuticals, agrochemicals, and other biologically active compounds. Its specific structure and properties make it a valuable component in the development of new drug candidates and the creation of new chemical entities.
Used in Research Applications:
In the field of research, (R)-3-butanamidobutanoic acid tert-butyl ester is employed as a precursor in the synthesis of complex organic molecules. Its unique chiral properties allow for the exploration of novel chemical reactions and the development of innovative synthetic pathways.
Used in Drug Development:
(R)-3-butanamidobutanoic acid tert-butyl ester is used as a key intermediate in the development of new drug candidates. Its incorporation into the molecular structure of potential drugs can enhance their efficacy, selectivity, and overall performance in treating various medical conditions.
Used in Organic Synthesis:
As a chiral molecule, (R)-3-butanamidobutanoic acid tert-butyl ester is used in organic synthesis to create enantiomerically pure compounds. This is crucial for the development of drugs with improved pharmacological properties and reduced side effects, as the stereochemistry of a molecule can significantly impact its biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 1067647-39-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,7,6,4 and 7 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1067647-39:
(9*1)+(8*0)+(7*6)+(6*7)+(5*6)+(4*4)+(3*7)+(2*3)+(1*9)=175
175 % 10 = 5
So 1067647-39-5 is a valid CAS Registry Number.
1067647-39-5Relevant articles and documents
Acylation of β-Amino Esters and Hydrolysis of β-Amido Esters: Candida antarctica Lipase A as a Chemoselective Deprotection Catalyst
M?enp??, Harri,Kanerva, Liisa T.,Liljeblad, Arto
, p. 1226 - 1232 (2016)
N-Acylation by lipase A from Candida antarctica (CAL-A) in ethyl butanoate was applied to the kinetic resolution of tert-butyl esters of 3-amino-3-phenylpropanoic acid (E>100), 3-amino-4-methylpentanoic acid (E>100) and 3-aminobutanoic acid (E=60) on 1.0-2.0 m scale. With the N-acylated resolution products, the exceptional ability of CAL-A to hydrolyse amides and bulky tert-butyl esters was then studied. In all N-acylated tert-butyl esters, chemoselectivity favoured the amide bond cleavage. The tert-butyl ester bond was left intact with 3-amino-3-phenylpropanoate, whereas with 3-amino-4-methylpentanoate and 3-aminobutanoate the CAL-A-catalysed hydrolysis of tert-butyl ester followed the amide hydrolysis.
