106852-98-6Relevant articles and documents
Long-acting Dihydropyridine Calcium Antagonists. Part 8. A Comparison of the Pharmacological and Pharmocokinetic Properties of Amlodipine with its Carba and Thio-bioisoesters
Alker, David,Burges, Roger A.,Campbell, Simon F.,Carter, Anthony J.,Cross, Peter E.,et al.
, p. 1137 - 1140 (2007/10/02)
In order to evaluate the contribution to the overall pharmacokinetic and pharmacological profile of amlodipine made by the side-chain ether oxygen atom and the intramolecular hydrogen bond to the DHP ring NH proton, the profile of amlodipine was compared