106859-54-5

Basic information

• Product Name: N-[3-(Diethylamino)propyl]-3-[3-(trifluoromethyl) phenoxy]-1-azetidinecarbothioamide, oxalate
• Synonyms: N-[3-(Diethylamino)propyl]-3-[3-(trifluoromethyl) phenoxy]-1-azetidinecarbothioamide, oxalate
• CAS NO: 106859-54-5
• Molecular Weight: 479.521
• Mol File: 106859-54-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[3-(Diethylamino)propyl]-3-[3-(trifluoromethyl) phenoxy]-1-azetidinecarbothioamide, oxalate(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(Diethylamino)propyl]-3-[3-(trifluoromethyl) phenoxy]-1-azetidinecarbothioamide, oxalate(106859-54-5)
• EPA Substance Registry System: N-[3-(Diethylamino)propyl]-3-[3-(trifluoromethyl) phenoxy]-1-azetidinecarbothioamide, oxalate(106859-54-5)

Safety Data

• Hazardous Substances Data: 106859-54-5(Hazardous Substances Data)

Upstream product

• 76263-23-5 3-[3-(trifluoromethyl)phenoxy]azetidine 
• 108-20-3 di-isopropyl ether 
• 2626-52-0 3-(N,N-diethylamino)propyl isothiocyanate 

Relevant articles and documents

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides

A method of treating animals to obtain muscle relaxation and/or to relieve anxiety is disclosed utilizing novel and known 3-aryloxy and 3-arylthioazetidinecarboxamides having the formula: STR1 wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo substituted pyridyl, phenyl or substituted phenyl; R1 and R2 are hydrogen, loweralkyl, aryl, allyl groups, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl and diloweralkylaminoalkyl, and R1 and R2 when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical; R3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof and pharmaceutical salts thereof and hydrates thereof when they are possible.

3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics

Novel 3-aryloxy and 3-arylthioazetidinecarboxamides having utility in a method of treating convulsions and epilepsy and compositions therefor are disclosed having the formula: STR1 wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo-substituted-pyridyl, phenyl or substituted phenyl; R1 and R2 are selected from hydrogen, loweralkyl, aryl, allyl, substituted allyl, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl, diloweralkylaminoloweralkyl, and R1 and R2 when taken with the adjacent nitrogen atom may form a heterocyclic radical; R3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof, excepting that when R3 is hydrogen, Z is oxygen, B is oxygen, and Ar is phenyl or phenyl substituted by trifluoromethyl or aminocarbonyl, then R1 and R2 cannot be a combination of hydrogen and loweralkyl, and the further exception that when R3 is hydrogen, Z is oxygen, B is oxygen, and Ar is phenyl or phenyl substituted by fluoro, loweralkyl, loweralkoxy, trifluoromethyl, acetyl, or aminocarbonyl, then R1 and R2 cannot both be hydrogen.