1068601-77-3Relevant articles and documents
Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study
Chen, Austin,Dubé, Daniel,Dubé, Laurence,Gagné, Sébastien,Gallant, Michel,Gaudreault, Mireille,Grimm, Erich,Houle, Robert,Lacombe, Patrick,Laliberté, Sébastien,Liu, Suzanna,MacDonald, Dwight,MacKay, Bruce,Martin, David,McKay, Dan,Powell, David,Lévesque, Jean-Fran?ois
, p. 5074 - 5079 (2010)
Time-dependent inhibitors of CYPs have the potential to perpetrate drug-drug interactions in the clinical setting. After finding that several leading compounds in a novel series of substituted amino propanamide renin inhibitors inactivated CYP3A4 in an NA