106874-91-3

Basic information

• Product Name: 5-BroMo-2-MethylaMino-benzonitrile
• Synonyms: 5-BroMo-2-MethylaMino-benzonitrile
• CAS NO: 106874-91-3
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.05858
• Mol File: 106874-91-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-BroMo-2-MethylaMino-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-2-MethylaMino-benzonitrile(106874-91-3)
• EPA Substance Registry System: 5-BroMo-2-MethylaMino-benzonitrile(106874-91-3)

Safety Data

• Hazardous Substances Data: 106874-91-3(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 937-23-5 4-bromo-N-nitroso-N-methylaniline 
• 553-90-2 Dimethyl oxalate 
• 39263-32-6 2-amino-5-bromobenzonitrile 

Downstream Products

• 106874-95-7 5-bromo-N-(2-bromopropionyl)-N-methyl-2-cyanoaniline 
• 39573-20-1 (5-bromo-2-(methylamino)phenyl)(phenyl)methanone 

Relevant articles and documents

Enantioselective Intramolecular Copper-Catalyzed Borylacylation

An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon–boron bond provides a platform for a wide array of diversification.

A NEW SYNTHESIS OF 4-AMINO-2-QUINOLINONES

Addition of Grignard or organolithium reagents to N-(α-haloacyl)-N-alkylsubstituted anthranilonitriles (e.g.N-(2-bromopropionyl)-N-methyl-2-cyanoaniline)induced anion formation followed by cyclization to 4-amino-2-quinolinones (e.g. 4-amino-1,3-dimethyl-2-quinolinone (10)).Substrates lacking α-hydrogen atoms, such as N-α-bromoisobutyryl)-2-cyanoaniline, also yielded 3,3-dimethylquinolinedione (9b) by cyclization.In these cases the initial step is a halogen-metal exchange reaction.