106898-37-7

Basic information

• Product Name: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile
• Synonyms: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile
• CAS NO: 106898-37-7
• Molecular Formula: C₉H₇N₅
• Molecular Weight: 185.18538
• Mol File: 106898-37-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.37
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile(106898-37-7)
• EPA Substance Registry System: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile(106898-37-7)

Safety Data

• Hazardous Substances Data: 106898-37-7(Hazardous Substances Data)

Usage

General Description

5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile is a chemical compound with the molecular formula C9H7N5. It is a pyrazole derivative with a cyano group attached to the 4-carbon position and an amino group at the 5-carbon position. The pyridin-4-yl group is attached to the 1-carbon position of the pyrazole ring. 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile has potential applications in pharmaceutical and chemical research due to its structural features and properties. It may be studied for its potential biological activities and medicinal properties, as well as its use as a building block in organic synthesis. Further research and development of 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile may lead to the discovery of new drugs, agrochemicals, and materials with valuable properties.

Upstream product

• 27256-91-3 4-pyridylhydrazine 
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• 20815-52-5 4-hydrazinopyridine hydrochloride 

Relevant articles and documents

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar1) determined this to be a tight binding region with little room for modification. As predicted from the model, a large variety of modifications could be incorporated into the hydrazone aryl ring. This work led to GSK-3 inhibitors in the low nano-molar range.