106931-78-6

Basic information

• Product Name: Fluocinolone Acetonide-21-carboxylic Acid
• Synonyms: Fluocinolone Acetonide-21-carboxylic Acid;Fluocinolone Impurity A;(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3,20-dioxo-pregna-1,4-dien-21-oic acid;KUVGGCPFHYXHKI-BDQUCZKRSA-N
• CAS NO: 106931-78-6
• Molecular Formula: C24H28F2O7
• Molecular Weight: 466.4717264
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 106931-78-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 584.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 2.39±0.54(Predicted)
• CAS DataBase Reference: Fluocinolone Acetonide-21-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: Fluocinolone Acetonide-21-carboxylic Acid(106931-78-6)
• EPA Substance Registry System: Fluocinolone Acetonide-21-carboxylic Acid(106931-78-6)

Safety Data

• Hazardous Substances Data: 106931-78-6(Hazardous Substances Data)

Usage

Description

Fluocinolone Acetonide-21-carboxylic Acid is a derivative of Fluocinolone Acetonide, a corticosteroid with potent anti-inflammatory and immunosuppressive properties. It is characterized by its ability to modulate the body's immune response, making it a valuable compound in the field of dermatology.

Uses

Used in Dermatology:
Fluocinolone Acetonide-21-carboxylic Acid is used as a topical medication for the treatment of various skin conditions characterized by inflammation, itching, and redness. Its application in dermatology is due to its ability to reduce skin inflammation and provide relief from itching, making it an effective treatment for conditions such as eczema, psoriasis, and contact dermatitis.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Fluocinolone Acetonide-21-carboxylic Acid is used as an active ingredient in the formulation of corticosteroid creams, ointments, and gels. Its incorporation into these formulations is due to its potent anti-inflammatory and immunosuppressive effects, which help to alleviate the symptoms of various skin disorders and improve the patient's quality of life.
Used in Research and Development:
Fluocinolone Acetonide-21-carboxylic Acid is also utilized in research and development for the discovery of new therapeutic agents with improved efficacy and reduced side effects. Its unique properties make it a valuable compound for studying the mechanisms of inflammation and immune regulation, potentially leading to the development of novel treatments for a wide range of inflammatory and autoimmune diseases.

Upstream product

• 13242-30-3 2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde 
• 67-73-2 fluocinolone Acetonide 

Relevant articles and documents

A concise access to a new class of selective anti-inflammatory steroid derivatives

The 17β-thiomethyl-16α,17α-ketal motif of a new class of selective anti-inflammatory androstane derivatives useful in the treatment of asthma is readily constructed by a new radical degradation of the corticosteroid side chain.