106956-32-5

Basic information

• Product Name: HUMAN ONCOSTATIN M
• Synonyms: ONCOSTATIN M, HUMAN;ONCOSTATIN M, HUMAN, RECOMBINANT;OSM;RHOSM;REC ONCOSTATIN M (HUMAN);REC OSM (HUMAN);RECOMBINANT HUMAN ONCOSTATIN M;HUMAN OSM
• CAS NO: 106956-32-5
• Molecular Formula: Unspecified
• Molecular Weight: 0
• EINECS: 200-835-2
• Mol File: 106956-32-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• CAS DataBase Reference: HUMAN ONCOSTATIN M(CAS DataBase Reference)
• NIST Chemistry Reference: HUMAN ONCOSTATIN M(106956-32-5)
• EPA Substance Registry System: HUMAN ONCOSTATIN M(106956-32-5)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37
• WGK Germany: 3
• Hazardous Substances Data: 106956-32-5(Hazardous Substances Data)

Usage

Description

Human Oncostatin M (OSM) is a cytokine produced by activated T cells, monocytes, and Kaposi's sarcoma cells. It shares structural and functional similarities with leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and ciliary neurotrophic factor (CNTF). OSM plays a role in various biological processes, including cell growth, differentiation, and inflammation.

Uses

Used in Cartilage Regeneration:
Human Oncostatin M is used as a stimulant for bovine full-depth cartilage explants, promoting cartilage regeneration and repair.
Used in Stem Cell Culture:
In the field of regenerative medicine, Human Oncostatin M is used as a growth factor for culturing embryonic stem cells in standard minimum essential medium-α, supporting their growth and differentiation into various cell types.
Used in Pharmaceutical Research:
OSM is utilized in pharmaceutical research to study its effects on cell growth, differentiation, and inflammation, as well as its potential role in the development of therapeutic agents for various diseases.
Used in Immunology and Inflammation Studies:
Human Oncostatin M is employed in immunology and inflammation research to investigate its role in immune responses and the regulation of inflammatory processes.
Used in Cancer Research:
OSM is also used in cancer research to explore its potential as a therapeutic target or biomarker for certain types of cancer, given its involvement in cell growth and differentiation.

Biochem/physiol Actions

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. It can exert both stimulatory and inhibitory effects on cell proliferation. OSM stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi′s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release [e.g. interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte-colony-stimulating factor (G-CSF)] from endothelial cells.