107-30-2

Basic information

• Product Name: Chloromethyl methyl ether
• Synonyms: CHLOROMETHYL METHYL ETHER
• CAS NO: 107-30-2
• Molecular Formula: C₂H₅ClO
• Molecular Weight: 80.5135
• EINECS: -0
• Product Categories: API Intermediate
• Mol File: 107-30-2.mol
• Article Data: 43

Chemical Properties

• Melting Point: -103.5°C
• Boiling Point: bp 59°
• Flash Point: 15 ºC
• Appearance: colorless or light yellow liquid
• Density: d420 1.0605
• Vapor Pressure: 218mmHg at 25°C
• Refractive Index: nD20 1.39737
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• Water Solubility: decomposes
• CAS DataBase Reference: Chloromethyl methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: Chloromethyl methyl ether(107-30-2)
• EPA Substance Registry System: Chloromethyl methyl ether(107-30-2)

Safety Data

• Hazard Codes: F:Flammable;;
• Statements: R45:; R11:; R20/21/22:
• Safety Statements: S53:; S45:
• Hazardous Substances Data: 107-30-2(Hazardous Substances Data)

Usage

Chemical Description

Chloromethyl methyl ether is used to add the MOM group to (S)-BINOL.

InChI:InChI=1/C2H5ClO/c1-4-2-3/h2H2,1H3

Upstream product

• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 109-87-5 Dimethoxymethane 
• 115-10-6 Dimethyl ether 
• 38870-89-2 Methoxyacetyl chloride 
• 37559-64-1 methoxymethyl benzenesulfenate 
• 27490-32-0 tributyl(methoxymethyl)stannane 
• 625-45-6 2-methoxyacetic acid 
• 142-61-0 Hexanoyl chloride 
• 16520-04-0 methoxymethyl radical 
• 112-13-0 n-decanoyl chloride 
• 111-64-8 n-octanoic acid chloride 
• 7647-01-0 hydrogenchloride 
• 7782-50-5 chlorine 

Downstream Products

• 765-50-4 2-Chloromethylthiophene 
• 31600-55-2 benzyl methoxymethyl ether 
• 67036-97-9 1,3,7,9-tetramethyldipyrromethene hydrochloride 
• 66947-91-9 5-(chloromethyl)-6-methyluracil 
• 531-14-6 coproporphyrin I 
• 874005-08-0 8-chloromethyl-5-hydroxy-7-methoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 742097-95-6 6-chloromethyl-5-hydroxy-7-methoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 99172-89-1 (α-methoxy-benzyl)-methoxymethyl ether 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 108994-34-9 methoxymethyl-phenyl-carbamoyl chloride 
• 5779-96-4 3-methoxy-2-(methoxymethyloxy)benzaldehyde 
• 116603-71-5 O-methoxymethyl-N,N-phthaloyl-L-tyrosin-ethyl ester 
• 5779-98-6 O-methoxymethylisovanillin 

Relevant articles and documents

Chain carbonylation of methoxymethyl chloride by using AgSbF6 catalyst under high pressure of CO

The chain carbonylation of methoxymethyl chloride (1) by the use of AgSbF6 catalyst smoothly proceeded under high pressure of carbon monoxide to give methyl methoxyacetate after treatment with methanol. The reaction was highly dependent on the CO pressure and the reaction temperature, indicating the presence of equilibrium processes. From the temperature dependence of the equilibrium constant, the enthalpy change of the reaction was calculated to be -25.4 kJ mol-1.

Monodisperse microbeads of hypercrosslinked polystyrene for liquid and supercritical fluid chromatography

Monodisperse styrene-divinylbenzene (1 wt %) copolymer microbeads are obtained via the elaborate method of high-productivity precipitation polymerization. The crosslinking of this copolymer with chloromethyl methyl ether in the presence of Friedel-Crafts catalyst yields porous hypercrosslinked polymers with degrees of crosslinking that range from 200 to 500%. Microbead sorbents are shown to be suited for selective stationary phases for high-performance liquid chromatography and supercritical fluid chromatography.

Notiz zur Herstellung von Chloromethylmethylether aus Methoxyessigsaeure

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A novel, convenient synthesis of chloromethyl methyl ether

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Synthesis of methoxymethylhexachloroantimonate

1. A method was developed for the synthesis of methoxymethylhexachloroantimonate, in which connection all of the operations were carried out in vacuo. 2. The decomposition into molecular forms, which is characteristic for MMH solutions, depends to a large degree on the polarity of the medium.

A modified low-cost preparation of chloromethyl methyl ether (MOM-Cl)

The versatile reagent chloromethyl methyl ether (MOM-Cl) is synthesized by using inexpensive starting materials in a large scale. A modification of the existing methods reduces material costs by more than 80%.

PROCESS FOR PREPARING AN ALKOXYMETHYL ALKYNYL ETHER COMPOUND HAVING A TERMINAL TRIPLE BOND

The present invention provides a process for preparing an alkoxymethyl alkynyl ether compound having a terminal triple bond of the following formula (4):H-CtriplebondC(CH2)aOCH2OCH2R (4), wherein R represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, and "a" represents an integer of 1 to 10, the method comprising subjecting an alkynol compound having a terminal triple bond of the following formula (1): H-CtriplebondC(CH2)aOH (1), wherein "a" is as defined above, to an alkoxymethylation with a halomethyl alkyl ether compound of the following formula (3): RCH2OCH2X (3), wherein X represents a halogen atom, and R is as defined above, in the presence of a dialkylaniline compound of the following formula (2): [CH3(CH2)b][CH3(CH2)c]NC6H5 (2), wherein b and c represent, independently of each other, an integer of 0 to 9, to form the alkoxymethyl alkynyl ether compound (4) having a terminal triple bond.

Fluorine analogs of dicamba and tricamba herbicides; Synthesis and their pesticidal activity

Fluorine analogs of the dicamba and tricamba herbicides were synthesized. Their herbicide activities were compared with the activities of the pattern herbicides dicamba and tricamba.

Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping

The high genomic instability of non-small cell lung cancer tumors leads to the rapid development of resistance against promising EGFR tyrosine kinase inhibitors (TKIs). A recently detected triple mutation compromises the activity of the gold standard third-generation EGFR inhibitors. We have prepared a set of trisubstituted imidazoles with a rigidized 7-azaindole hinge binding motif as a new structural class of EGFR inhibitors by a target hopping approach from p38α MAPK inhibitor templates. On the basis of an iterative approach of docking, compound preparation, biological testing, and SAR interpretation, robust and flexible synthetic routes were established. As a result, we report two reversible inhibitors 11d and 11e of the clinically challenging triple mutant L858R/T790M/C797S with IC50 values in the low nanomolar range. Furthermore, we developed a kinome selective irreversible inhibitor 45a with an IC50 value of 1 nM against the EGFR L858R/T790M double mutant. Target binding kinetics and metabolic stability data are included. These potent mutant EGFR inhibitors may serve as a basis for the development of structurally novel EGFR probes, tools, or candidates.